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Design and synthesis of GSH-responsive NIR-II probe LJ-GSH Developing a fluorescent diagnostic probe for tumor applications, the ideal imaging agent should meet the following prerequisites: (1): NIR fluorescence emission for deep-tissue penetration and minimize auto-fluorescence

Lower levels of glutathione are associated with high blood sugar and result in oxidative stress and tissue damage

The expression of ZO-1, Occludin, SIRT1, STAT3, p-STAT3, RORt, IL-6, IL-1, TNF-, and -actin was examined using the method previously described (Yao et al., 2014)