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Definition of hyperprogression Hyperprogression was defined using the previously established criteria for solid tumors as progressive disease in the first 8 weeks after treatment initiation, a 10 mm minimum increase in the measurable lesions, plus: (i) an increase of 40% in the sum of target lesions compared with baseline and/or (ii) an increase of 20% in the sum of the target lesions compared with baseline plus the appearance of new lesions in at least two different organs

doi:10.1111/jsr.12430 Wickwire EM, Lettieri CJ, Cairns AA, Collop NA

They secrete a spectrum of profibrotic mediators, including TGF-1, IL-10, arginase-1, and CCL18, which promote fibroblast proliferation, myofibroblast differentiation, and excessive ECM deposition (109)

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