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Vitamin D has additionally been linked to the restoration of autophagic balance and immunoregulation in SLE, influencing T-cell activity, reducing inflammation, and promoting immune tolerance, supporting its potential as an adjunct therapy

According to different demonstrations, uric acid and albumin are the two major antioxidants in human plasma, contributing 24% and 33%, respectively, of the total antioxidant activity [28]

Therefore, it is necessary to explore the correlation between MTHFR gene polymorphisms and serum folate levels and CRC risk, and to verify that MTHFR gene variants are one of the genetic susceptibility factors of CRC, which can help to provide a reference for personalized diagnosis and treatment and provide a new idea and direction for targeted therapy

2 Molecular and functional organization of adipose tissue AT plays an essential role in metabolic regulation beyond simple energy storage ( Biochemical characteristics of AT have revealed complex regulatory networks that control energy metabolism