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Being a measure of the sedimentation rate per unit of centrifugal field (i.e., the rate of boundary movement per unit centrifugal force), sedimentation coefficient, s , is the migration parameter that characterizes size and density of a protein molecule, where larger and more compact molecules sediment faster and have higher s value

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1.5 micrograms in the UK, 2.4 micrograms in the US and 4.0 micrograms in Europe (EFSA) but scientists suggest that these recommendations may be too low and that four to 20 micrograms a day is more appropriate to prevent B12 deficiency