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When FASN lox/lox MEFs were infected with adenoviral particles expressing Cre to eliminate the conditional FASN allele prior to PyMT, KRAS (G12D), or HER2 (A775_G776insYVMA) expression (FASN / -PyMT, FASN / -KRAS, and FASN / -HER2, respectively), virtually no colonies were recovered (Fig

Suhail S, Zajac J, Fossum C, Lowater H, McCracken C, Severson N, et al

Thus, these altered metabolomic changes and perturbed balance in the motor cortex of prpTDP-43 A315T mice suggest a deficit in energy homeostasis and increased oxidative stress, events that are associated with problems with mitochondrial integrity and function

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