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Moreover, the mRNA expression of Cntf and its receptor was found to be upregulated

synergistically increase the chemotherapeutic effects of anti-neoplastic drugs in the management of brain cancers [206]

CAFs upon activation secretes growth factors, cytokines, and ECM molecules including TGF-, matrix metalloproteinases (MMPs), hepatocyte growth factor (HGF), and fibroblast growth factors (FGFs), which are implicated in tumor development, invasion, and metastasis (120)