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Further, lipocalin 2 (LCN2) was significantly increased in the hippocampus of diabetic mice, and its expression was weakened after AICAR treatment, suggesting that LCN2 may be involved in the development of ferroptosis in the hippocampus of mice 332

Symptoms and Health Implications : Reduced glutathione levels are associated with increased susceptibility to oxidative stress, chronic diseases, and compromised immune function

Annu Rev Biochem 71:537592 Botta D, White CC, Vliet-Gregg P, Mohar I, Shi S, McGrath MB, McConnachie LA, Kavanagh TJ (2008) Modulating GSH synthesis using glutamate cysteine ligase transgenic and gene-targeted mice

Low levels of B12 could potentially lead to a decrease in the production of serotonin ultimately causing or contributing to depression