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In addition to its role in cancer, GPR81 is expressed in neurons, astrocytes, and endothelial cells across the brain, retina, and bloodbrain barrier, as well as in adipose and liver tissues, where it influences lipolysis and gluconeogenesis, thus impacting systemic energy balance [74,75,76]

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Received 24 April 2022

In addition to regulating the gene expression within the cells that produce them, miRNAs can also modulate the function of other cell populations, including monocytes and macrophages, through paracrine signaling via extracellular vesicles [43]