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Increases Mitochondrial Function and Biogenesis MOTS-C doesnt just improve existing mitochondrial function it stimulates the creation of new, healthy mitochondria

Aging is another major factor, as it slows down the skins natural turnover, making it harder for melanin to be expelled, which increases the likelihood of dark spot formation

Haem in macrophages is first catabolized by haem oxygenases, generating iron, carbon monoxide and biliverdin [28, 29]

Miquelianin-rich lotus leaf extract (LLE) significantly increases the expression of 3-adrenergic receptor (3-AR) and p-AMP-activated protein kinase (AMPK)/AMPK ratio in the inguinal white adipose tissues of in vitro models established by the differentiation of 3T3-L1 cells and in high-fat diet-induced obese mice, thus significantly decreasing the protein expression of the mitophagy markers, PINK1, Parkin, Beclin1 and LC3B, up-regulating the expressions of p62 and Drp1, increasing the expression of beige fat-enriched marker proteins nuclear respiratory factor 1 (Nrf1), mitochondrial transcription factor A (TFAM), PPAR, and cytochrome oxidase subunit VII a (Cox7a), and upregulated the protein levels of mitochondrial biogenesis markers, silent information regulator 1 (SIRT1), peroxisome proliferator-activated receptor coactivator 1 (PGC-1), uncoupling protein 1 (UCP1) and fibroblast growth factor 21 (FGF21) levels