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The response rates were higher for cyclosporine A and methotrexate in second-line treatment than in first-line treatment (57.3% vs 68.8% and 29.1% vs 62.7%, respectively) whereas the higher response rates for cyclophosphamide was in first-line treatment (68.2% vs 57.4%)

Int J Neurosci 114:10011011 Singh NP, McCoy MT, Tice, RR, Schneider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells

Additionally, TFAM (Mitochondrial Transcription Factor A) plays a role in regulating mtDNA transcription and replication as part of the mitochondrial base excision repair process (202)

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