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SIRT1 plays a key role in protection against CVDs, metabolic syndrome, obesity, vascular endothelial function, and ischemia-reperfusion damage (Kane and Sinclair, 2018)

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6.3 Inhibition of bone destruction and cartilage damage Clinical trials have shown that the use of tocilizumab in combination with methotrexate in patients with moderate-to-severe RA can significantly decrease the level of the bone remodeling markers, C-terminal cross-linked telopeptide of type I collagen and MMP-degraded type II collagen, and inhibit the bone remodeling process (282)