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Since the liver is the major source of IGF and IGFBP production, they examined whether levels of IGFs (IGF-1 and IGF-11) and IGFBPs (IGFBP-1 and IGFBP-3) differed when insulin was infused into the portal or peripheral vascular system [13]

(StatPearls Publishing, 2022)

Mechanisms (Preclinical Only) Rodent and in vitro studies report modulation of the nitric oxide system via SrcCaveolin1eNOS signaling and context dependent effects on vascular tone

Their simultaneous activation does not produce simple pathway redundancy but rather engages complementary aspects of the tissue repair response, providing the biological rationale for studying whether combination produces additive or synergistic repair outcomes exceeding either peptide alone