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Therefore, developing effective yet low-toxicity therapeutic agents for CRC may constitute a pivotal strategy to enhance overall treatment efficacy

An 8-week-old germ-free female C57BL/6J mice were housed in an isolator (CEP Standard Safety, McHenry, IL, USA) with open cages in the University of Alberta Axenic Mouse Research Unit

There is a great interest in the biomedical area in the fields of tissue regeneration and repair, in the application of biomaterial technologies (Capuana et al., 2022