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Such TBI-induced actions, whether occurring early or later in life, can readily increase the vulnerability of the brain to other neurodegenerative events as detailed in the two hit hypothesis of the Latent Early-life Associated Regulation (LEARn) model of Lahiri et al., [92, 93], whereby genetic and environmental risk factors combine in an epigenetic pathway to trigger the etiology of a later neurobiological disorder (such as TBI leading to AD)

Over the years, Dr

Generally, six to eight weeks old inbred male and female Swiss albino mice (1:1) weighing 25 to 30 g were requisitioned from the colony maintained under the controlled conditions of temperature (23 2C), humidity (50 5%) and 12 h of light and dark cycle, respectively