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Mechanistically, this variant disrupts SP1 transcription factor binding to the JMJD3 promoter, reducing its expression in vascular smooth muscle cells (SMCs)

doi:10.1152/ajpendo.2000.279.3.E501 Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R

In oxidative stress disorders, including stroke, GSH levels are depleted, and reduced brain GSH levels are associated with increased stroke risk (Zhang et al., 2021d)