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For treatment, they may help reduce swelling and stop pain signals from being transmitted to the brain

Common gastrointestinal side effects include: Nausea the most frequently reported side effect, particularly during dose escalation Vomiting often linked to nausea and typically dose-dependent Diarrhoea and constipation both have been reported, reflecting altered gut motility Decreased appetite a desired therapeutic effect, but one that requires monitoring to ensure adequate nutrition Severe or prolonged vomiting and diarrhoea can lead to dehydration and, in some cases, acute kidney injury (AKI)

[DOI] [PubMed] [Google Scholar] [179].Rayman MP, Taylor EW, Zhang J