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Similarly, IGF-1, which is homologous to insulin and has partial common receptor affinity, can activate post-receptor signaling in neurons to ameliorate diabetic neuropathy (50)

100 Increased permeability exacerbates metabolic endotoxemia, thus triggering immune response and IR through toll-like receptor 4 (TLR4), CD14, 101 and G protein-coupled receptor (GPR) 41/43