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Genes 14:1285 Gillette-Guyonnet S, Van Kan GA, Alix E, Andrieu S (2007) IANA (International academy on nutrition and aging) expert group: weight loss and Alzheimers disease

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Smith-Magenis syndrome (a congenital disorder due to a haplo-insufficiency of the retinoic acid-induced 1 gene, involved in the regulation of the expression of circadian genes) patients present with an inverted rhythmic melatonin secretion and sleep difficulties that can be managed with melatonin administration in the evening and -adrenergic blockers during the day to reduce melatonin secretion (82)