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Phytotherapy Research, 21 (1), 1725

Because TXNIP expression decreases under conditions of reduced ROS 44 , we hypothesized that metformin lowers intracellular ROS by enhancing antioxidant defenses and NADPH availability

A., Moss, D

In terms of pharmacological effects, it stimulates the release of growth hormone (GH) from the anterior pituitary gland by activating the growth hormone releasing peptide receptor