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European Joint Programme on Rare Diseases (Improve-PSP)

In preclinical heart failure models, NNMT enzyme inhibition markedly reduced cardiac 1-MNA (by 77.1%), improved cardiac function, reduced left ventricular hypertrophy and fibrosis, and decreased pro-inflammatory gene expression

There are some medications which are used for other indications but that have modest effect in lowering uric acid levels, such as losartan (Cozaar), used for hypertension, and fenofibrate (Tricor), used for elevated triglycerides, but these only infrequently can sufficiently lower uric acid level