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Mitochondrial respiratory chain complexes I (NADH-CoQ reductase complex), II (succinate dehydrogenase complex), III (cytochrome bc-1 complex) can, under different metabolic stress, produce ROS that damage the mitochondrial membrane, resulting in lipid peroxidation and ultimately leading to ferroptosis

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That is why researchers are interested in LL-37 as a blueprint for new antimicrobials, as antibiotic resistance has become a severe global threat

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