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Activity-based probes as a tool for functional proteomic analysis of proteases

Therefore, a deeper understanding of the regulation, interactions with other metabolic pathways and mechanism of -PL biosynthesis, could facilitate a rational genetic approach, integrating high-throughput techniques, omics data and in silico models, and then provide extensive information on the regulatory and biosynthetic systems of -PL production and promote enhanced metabolic flux towards -PL biosynthesis [14]

2013 Sep 15;191(6):3419-29

Studies have shown that GPX4 and Vitamin E work synergistically to protect cells, as Vitamin E inhibits ALOXs activity and reduces lipid peroxidation, thus inhibiting ferroptosis [60]