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These cytokines reach the brain and affect regions implicated in mood, motivation, and energy, contributing to symptoms such as fatigue, persistent sadness, irritability, and reduced motivation

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Jason Brause, MAFelicitas A

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Hepatology 46 , 13921403 (2007)

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Overexpression of cyclooxygenase-2 (COX2) is also responsible for dopaminergic neuronal loss via oxidative stress-mediated inflammation

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