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Furthermore, PKM2 activation contributes to the intracellular accumulation of succinate, a signaling metabolite that stabilizes HIF-1 and promotes interleukin-1 beta (IL-1) production during inflammatory responses (Tannahill et al., 2013)

Since the volunteers in this study were female athletes with consistent exercise habits, changes in SC may be attributed to factors such as exercise-induced fatigue, which can lead to protein changes and increased oxidative stress