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Some patients report a pale or yellowish tinge to the skin, and glossitis (a sore, red tongue) may develop

Thus, we tested in genetic mouse models whether a moderate increase in VEGFA expression (~two to threefold, as it occurs in response to hypoxia or oxidative stress in aged tissues) leads to increased agerelated progressive pathologies in the lens and the retina, and whether genetic targeting of NLRP3 inflammasome components or of its regulators can inhibit the manifestation of these common but distinct aging eye pathologies

For longterm storage (months to years), deep freezing at ~80C (112F) is recommended