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10.1038/nrc3278 21

Garner.RobergB.QianK.EatonM.TruscottJ

Indeed, insulin-stimulated phosphorylation of multiple TBC1D4 phosphosites was impaired in insulin-resistant muscle from diabetic or TNF-infused patients [99,100], and conversely, exercise-induced phosphorylation of TBC1D4 S711 was required for improved insulin action in mice [101,102]