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Some strategies take advantage of differences in GSH concentration to construct GSH-responsive prodrugs by introducing a sulfur bond that, in the presence of GSH, may achieve drug-responsive release at the tumor site and enhance anti-tumor effects

Moreover, all the AcM inclusion levels led to a decreased abundance of KOs encoding for the biosynthesis/metabolism of structural cell components, such as teichoic acid ( tagA , tagE , dltA , dltB , dltC , dltD , cpoA , mgs and bcrC ) and peptidoglycan ( murA , murB , murC , murD , murE , murF , murG , bcrC , dacC , ddl , mraY , pbp2A and pbpB ) of which murF , murG , mraY and ddl together with alr also led to a decrease in intrinsic vancomycin resistance