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doi:10.4081/ejh.2021.3331 2023 The Author(s)

Whereas histone acetylation is linked to transcriptional activation, histone methylation can either be repressive or activating

It consumes substantial oxygen, so it is prone to lipid peroxidation, poor antioxidant capacity, and higher ferroptosis sensitivity

In our experiments, the concentration of CB-839 needed for effective, functional glutaminase inhibition varied from 10 nM to 1 M, and the antiproliferative IC 50 was determined as 0.41 M for the HG-3 cell line and 66.2 M for the MEC-1 cell line