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Key findings from this body of work include: AOD-9604 stimulated proteoglycan synthesis in bovine cartilage explants in a dose-dependent manner The peptide promoted the differentiation of mesenchymal stem cells toward the chondrocyte lineage In a rabbit model of osteoarthritis, intra-articular injection of AOD-9604 was associated with improved cartilage scores and reduced degradation markers compared to controls The effects were observed without the IGF-1 elevation or metabolic side effects associated with full-length growth hormone Clinical Observations Physicians prescribing AOD-9604 in clinical peptide therapy settings have reported improvements in joint comfort and function among their patients

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The primary target would be the annulus fibrosus, which is the tough outer ring that tears during a herniation

doi: 10.1152/ajpgi.1999.276.3.G639 18