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No significant difference in food intake was observed between treated and control mice in related studies, indicating that its antiobesity effect mainly depends on regulating fat metabolism rather than suppressing appetite - a unique advantage in obesity research

Due to these opposing concepts, the concordance between both tests is low

When the light signal is positive, the SCN secretes gamma-amino butyric acid, responsible for the inhibition of the neurons that synapse in the paraventricular nucleus (PVN) of the hypothalamus, consequently the signal to the pineal gland is interrupted and melatonin is not synthesized