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This release can occur through different mechanisms, such as nanoparticle dissolutionan instability that arises under specific pH conditions, typically at lower pH, leading to matrix dissolutionand polymer swelling, a process in which nanoparticles swell at certain pH conditions, both ultimately resulting in drug release (Karimi et al., 2016)

You end up with oxidative damage, inflammation and brain injury

Intranasal delivery extends the effective CNS half life because the peptide is transported directly along olfactory and trigeminal nerve pathways into cerebrospinal fluid and hippocampal interstitial space, bypassing systemic circulation and hepatic metabolism

TIME Magazine named him as one of the 100 Most Influential People in the World in 2014, and one of the 50 Most Influential People in Healthcare in 2018