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Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response

J Clin Oncol 2011;29:2952-5

Frontiers in Cell and Developmental Biology , 9 , 688605

Ammonia is both a final and intermediate metabolic product of various biochemical pathways in the body and must be removed as quickly as possible, given its high toxicity