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210,244 A prospective multicenter phase I clinical trial showed that the administration of riluzole in the early stage of SCI significantly improves the ASIA score without causing serious adverse events

For example, Rho-kinase inhibitors, which reduce TM cell contractility, have been shown to enhance AH outflow, suggesting that similar gene-based approaches could be effective in improving TM function and managing IOP (292)

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Around 33% of these then advance to Phase III, which focuses on adverse reactions of the drug and investigate their potency (Sayyaed et al., 2023)