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While ROS at low levels function as signaling molecules involved in transcriptional regulation, proliferation, differentiation and immune responses (94,95), excessive ROS production can overwhelm the antioxidant defense system, leading to oxidative stress

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Meanwhile, during the ferroptosis, cells release oxygenated phosphatidylethanolamines on the outer plasma membrane, which are detected by macrophages via toll-like receptor 2, allowing the clearance of ferroptosis cells (76)