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DNAM-1 has been reported to be an activating receptor on NK cells [152]

Hormonal fluctuations, particularly during pregnancy or when taking oral contraceptives, can trigger melasma, a type of hyperpigmentation characterized by symmetrical brown patches typically appearing on the face

ASH 2019 134(Suppl 1), 2019

The disruption of IL-1 and NLRP3 can lead to impairment of the innate cellular immune response, which may have varying clinical implications during infections [13]