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Applying retinoids, AHAs, BHAs, or strong vitamin C during this window introduces irritants directly into a partially open dermal layer, which produces a much stronger irritation response than the same actives applied to intact skin

Storage Lyophilized powder: Should be stored in a freezer (-20C / -4F) for long-term stability, where it can remain stable for years

Patients who experience significant side effects at any dose can remain at that dose longer (6-8 weeks) before escalating, or step back to the previous dose temporarily before attempting escalation again

running 1mg daily and discarding 70mg when it expires