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However, provided variations in the water content within the sample are much smaller than the variations in the metabolite levels, variance shared between normalized metabolite signals can be assumed to arise largely from shared variance in metabolite concentrations [52]

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Ritvo ER, Freeman BJ, Scheibel AB, Duong T, Robinson H, Guthrie D, et al

In order to more clearly investigate the beneficial or deleterious role of astrocytes in the pathogenesis of MS, studies using genetic or pharmacological approaches have revealed a dichotomous behavior in a disease phase dependent manner