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doi: 10.1016/j.jid.2016.09.016 105 RezkAFKempDMEl-DomyatiMEl-DinWHLeeJBUittoJet al

This transformation is marked by the expression of T-bet and gamma interferon, an increase in PI3K/AKT signaling activity, and a subsequent loss of their suppressive function over effector T cells (142) ( Figure 6 )

[DOI] [PMC free article] [PubMed] [Google Scholar] [75].Karbowski M, Lee YJ, Gaume B, Jeong SY, Frank S, Nechushtan A, Santel A, Fuller M, Smith CL, Youle RJ

Methods for obtaining heavy chain antibodies and the variable domains are inter alia provided in the following references: WO 94/04678, WO 95/04079, WO 96/34103, WO 94/25591, WO 99/37681, WO 00/40968, WO 00/43507, WO 00/65057, WO 01/40310, WO 01/44301, EP 1134231, WO 02/48193, WO 97/49805, WO 01/21817, WO 03/035694, WO 03/054016, WO 03/055527, WO 03/050531, WO 01/90190, WO 03/025020, WO 04/041867, WO 04/041862, WO04/041865, WO 04/041863, WO 04/062551