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Targeting the USP7-PRMT6 epigenetic axis overcomes chemoresistance in breast cancer by coordinating H3R2me2a deposition and RNF168 methylation for DNA repair and ferroptosis blockade

Glutamine can act as an inducer of ferroptosis, promoting ferroptosis through its own hydrolysis, but this process requires cystine starvation [47]

MSCs primarily engage in immunomodulatory activities through cell-to-cell interactions with immune cells, including T cells, B cells, natural killer (NK) cells, macrophages, monocytes, dendritic cells (DCs), and neutrophils (252)

Because of this, activating PHD-2 either directly or indirectly may represent a novel approach to treating solid tumours