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Conversely, other studies propose that while excessive HO-1 activation might protect against heme-induced oxidative damage, it may also trigger atypical ferroptosis by generating excessive free iron through heme degradation ( Figure 4 )

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Role of HO-1 in regulating diabetic cardiomyopathy Diabetic cardiovascular disease is the microvascular and macrovascular disease of the cardiovascular system caused by diabetes, which includes coronary heart disease, diabetic cardiovascular autonomic neuropathy, and diabetic cardiomyopathy [84]