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Cellular and molecular mechanisms of 3,3'-diindolylmethane in gastrointestinal cancer

303 Moreover, hepatic iron accumulation can induce the transcription expression of ACSL4 by activating the transcription factor c-Myc, and further aggravate the development of MASH through ferroptosis

Additionally, iron chelating agents, including chloroiodohydroxyquine and its derivatives, as well as antioxidants, have shown efficacy in animal models of AD, though clinical trials are yet to be conducted (27,106,116)

This mechanism is further supported by garlic's ability to inhibit the stimulatory effects of aldosterone, Ang-II, and ADH on Na + transport (209)