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It is very common to not be properly hydrated on a daily basis, as we require plenty of fluids, and not just water (a combination of minerals and vitamins as well as water are essential to our health), to replenish what is lost through sweating, illnesses that involve gastroenteritis (vomiting, diarrhea), and more

1980 Jan;110(1):130-8

As an alternative possibility, the GPx1 deficiency in intestinal macrophages could be due to increased utilization of selenium for selenoprotein production elsewhere as serum GPx activity was increased in patients with active CD

Accordingly, the World Health Organization classifies G6PD-d based on the level of residual G6PD activity, with severe deficiency (Class I) causing chronic nonspherocytic hemolytic anemia and the least severe deficiency (Class IV) with little-to-no appreciable phenotype 8,11