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408 Tumor-associated senescent neutrophils (Naged, CXCR4 + CD62L low ) form unique mitochondria-dependent NETs to facilitate breast cancer lung metastasis

The classical mitochondrial pathway in apoptosis is related to the increased permeability of mitochondrial outer membrane, which enables some soluble proteins such as cytochrome c in the mitochondrial intermembrane space to be released into the cytoplasm, then apoptotic signaling pathways are activated, causing cell death

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Revision and final approval of the manuscript: CE, JM, MAB, and JC