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In some embodiments, the invention encompasses contacting one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy

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The telomerase-activation finding has been a defining mechanism feature of Epithalon since the early-2000s Khavinson-laboratory work, with implications for the broader anti-aging research framework around cellular replicative senescence