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For example, adduction of -dicarbonyls such as glyoxal and methylglyoxal to Lys and Arg residues is a form of PC ( Detection of PC can be performed by several methods that differ in sensitivity and specificity, many of which rely on derivatization of carbonyl groups with hydrazine-based compounds to generate stable hydrazones detectable by various approaches ( 3 The impact of lipid peroxidation-mediated protein carbonylation on protein turnover and function As amphiphilic molecules, RLAs can easily cross membranes, reaching almost any organelle within the cell, far from the site where they are formed (77, 78)

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Conflict of interest The authors declare that there is no conflict of interest