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TP53 rs1042522 TP53 encodes p53, often called "the guardian of the genome" a tumor suppressor protein that responds to cellular stress, DNA damage, and oxidative injury by triggering repair, cell cycle arrest, or programmed cell death

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In PD studies, adverse effects include worsening of symptoms such as tremor and stiffness along with fatigue, headache, constipation, increased irritability, and heightened sensations of hunger or thirst [18, 86, 123]

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