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Employing digital PCR (dPCR) and next-generation sequencing to longitudinally quantify mtDNA mutations in paired peripheral blood, tissue biopsies, and CSF will clarify their roles in residual inflammation, neurocognitive decline, and immunological failure

This allows for the medication to be absorbed through the oral mucosa, providing targeted local or systemic effects

Although there are significantly less study on mice, the loss of selectivity is also there in the mouse

Though average level of degeneration is lower in the ALA treatment groups regardless of IOP, there is no significant difference in ON grade among groups (t-test, p = 0.31