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(2023) employed high-performance liquid chromatography-tandem mass spectrometry (LC/MS) to analyze 408 PCOS patients, revealing significantly elevated serum levels of chenodeoxycholic acid (CDCA) and cholic acid (CA), which positively correlated with insulin resistance and hyperandrogenemia

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Pathway analysis of proteins correlated to PTR highlighted not just STEAP3, but also metabolic enzymes involved in glycolysis (HK1, PFKM, PKLR, BSG essential for lactate transporter relocation to the membrane upon its synthesis 69 ), the pentose phosphate pathway (RPIA, G6PDX, PGLS, PGD, TALDO1, PRPS1), ferroptosis (STEAP3, GPX1, GPX4, HBB-y, NQO1, PRDX2, GSR, SOD3, CAT), all consistent with recent literature in humans 1217