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The different cardiac expression of the type 2 iodothyronine deiodinase gene between human and rat is related to the differential response of the Dio2 genes to Nkx-2.5 and GATA-4 transcription factors

Glutathione is called the body's master antioxidant: - protects against oxidative stress - has anti-inflammatory effects - supports liver detoxification Deficient glutathione underlies the oxidative stress in aging Here's how to make enough glutathione PMID: 34439468 Glutathione is called the body's master antioxidant: - protects against oxidative stress - has anti-inflammatory effects - supports liver detoxification Deficient glutathione underlies the oxidative stress in aging Here's how to make enough glutathione PMID: 34439468 Glutathione is made of primarily glutamine, cysteine, and glycine, which are amino acids Glutathione synthesis is rate-limited by glycine (PMID: 29559876) Taking N-acetylcysteine (NAC) and glycine has been shown to increase glutathione levels (PMID: 17602868

Malondialdehyde (MDA) and 4-hydroxynonenal (HNE) (Figure 1), end products of lipid peroxidation, are discharged from destroyed hepatocytes into the space of Disse (Figure 2)