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Long-term human safety data does not exist, which is the main caution

Smart N, et al

doi: 10.1089/ars.2017.7351 91 OlesonBJBroniowskaKANaatzAHoggNTarakanovaVLCorbettJA

Semax works primarily through BDNF receptor (TrkB) modulation and immediate neurotransmitter effects (particularly dopamine and serotonin)it has human clinical trial data from Russian studies and rapid-onset cognitive effects